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Single Cell ​Sample Preparation​ Reengineered

Cellsonics is reengineering single-cell sample preparation to deliver the individual characteristics of each solid tissue sample for a precision medicine approach to the analysis, treatment, and diagnosis of disease.

Cellsonics SimpleFlow™ products are designed to enable any lab to obtain viable, heterogeneous cell populations from solid tissue samples in 10 minutes or less while maintaining the native gene expression of the individual cells. The dissociated cells are suitable to meet the demands of single cell analysis applications.

Technology

At Cellsonics, we believe that sample preparation should not compromise biologically meaningful data. We have combined Cellsonics’ SimpleFlow™ automated sample handling with cell-friendly, proprietary Bulk Lateral Ultrasonic™ (BLU™) energy to relieve researcher’s concerns.

Challenges often tied to enzymatic methods are eliminated, such as:

  • Heated incubation during enzyme dissociation alters cellular transcriptional activity profiles (including activated inflammatory and stress-related genes)
  • Complex workflows and overhandling can damage cell viability and rare surface markers
  • Rare cell types are frequently damaged or lost due to lack of protocol optimization
  • Tissue type-dependent, manually intensive dissociation protocols add to expense and output variability
SimpleFlow Tissue Dissociation System

Our simplified solution uses SimpleFlow™ technology to set new standards for obtaining single cells from solid tissue with unparalleled speed, quality, and sample integrity. In addition, the integration of novel BLU™ energy into a fluidic circuit in a single-use cartridge provides a complete automated dissociation workflow solution not possible using conventional methods. Following dissociation, cells are viable and ready for immediate downstream studies and applications, including FACS, NGS, and in vitro cell cultures.

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